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Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospectivecohort study

Di Cheng, Chunyan Hu, Rui Du, Hongyan Qi, Lin Lin, Xueyan Wu, Lina Ma, Kui Peng, Mian Li, Min Xu, Yu Xu, Yufang Bi, Weiqing Wang, Yuhong Chen, Jieli Lu

《医学前沿（英文）》 2020年 第14卷 第6期   页码 802-810 doi: 10.1007/s11684-019-0723-7

摘要： The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown. This study aimed to investigate this association in a community-dwelling population aged≥40 years in Shanghai, China. Oral glucose tolerance test was conducted during baseline and follow-up visits. Relative risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk. A total of 613 (10.3%) incident diabetes cases were identified during the follow-up visit after 4.5 years. Fasting plasma glucose, postload glucose, and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid (all s<0.05). The incidence rate of diabetes increased across the quartiles of serum uric acid (7.43%, 8.77%, 11.47%, and 13.43%). Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid (odds ratio (95% confidence interval) = 1.36 (1.06−1.73)). Stratified analysis indicated that the association was only observed in women. Accordingly, serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women.

关键词： incident diabetes     prospective study     uric acid    

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Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

《医学前沿（英文）》 2020年 第14卷 第6期   页码 752-759 doi: 10.1007/s11684-020-0813-6

摘要： This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirus disease 2019 (COVID-19). In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20, 2020. All patients were divided into an exposed group (CHM users) and a control group (non-users). After propensity score matching in a 1:1 ratio, 156 CHM users were matched by propensity score to 156 non-users. No significant differences in seven baseline clinical variables were found between the two groups of patients. All-cause mortality was reported in 13 CHM users who died and 36 non-users who died. After multivariate adjustment, the mortality risk of CHM users was reduced by 82.2% (odds ratio 0.178, 95% CI 0.076–0.418; <0.001) compared with the non-users. Secondly, age (odds ratio 1.053, 95% CI 1.023–1.084; <0.001) and the proportion of severe/critical patients (odds ratio 0.063, 95% CI 0.028–0.143; <0.001) were the risk factors of mortality. These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19.

关键词： COVID-19     CHM     mortality     a retrospective cohort study    

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fertility-sparing surgery for non-epithelial ovarian tumors to safely and successfully become pregnant---a Chineseretrospective cohort study among 148 cases

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

《医学前沿（英文）》 2018年 第12卷 第5期   页码 509-517 doi: 10.1007/s11684-017-0554-3

摘要：

This study was performed to evaluate the oncological and reproductive outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000 and August 31, 2015 from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overall survival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P=0.023), whereas histology significantly influenced OS. Cox regression analysis suggested that only histology was associated with PFS and OS (P<0.05). Among the 129 women who completed adjuvant chemotherapy (ACT), none developed amenorrhea. Among the 44 women who desired pregnancy, 35 (79.5%) successfully had 51 gestations including 35 live births without birth defects. Non-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy. Histology might be the only independent prognostic factor for PFS and OS. FSS followed by ACT appeared to have little or no effect on fertility. Meanwhile, postoperative pregnancy did not increase the PFS or OS. Use of gonadotropin-releasing hormone agonist was not beneficial for fertility.

关键词： malignant germ cell tumors     ovarian sex cord-stromal tumors     fertility-sparing surgery     prognosis     fertility    

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J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study

《医学前沿（英文）》 2023年 第17卷 第1期   页码 156-164 doi: 10.1007/s11684-022-0932-3

摘要： We aimed to investigate the relationship of dietary zinc intake with new-onset hypertension among Chinese adults. A total of 12,177 participants who were free of hypertension at baseline from the China Health and Nutrition Survey were included. Dietary intake was assessed by three consecutive 24-h dietary recalls combined with a household food inventory. Participants with systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg or diagnosed by a physician or under antihypertensive treatment during the follow-up were defined as having new-onset hypertension. During a median follow-up duration of 6.1 years, 4269 participants developed new-onset hypertension. Overall, the association between dietary zinc intake and new-onset hypertension followed a J-shape (P for non-linearity < 0.001). The risk of new-onset hypertension significantly decreased with the increment of dietary zinc intake (per mg/day: hazard ratio (HR) 0.93; 95% confidence interval (CI) 0.88–0.98) in participants with zinc intake < 10.9 mg/day, and increased with the increment of zinc intake (per mg/day: HR 1.14; 95% CI 1.11–1.16) in participants with zinc intake ≥ 10.9 mg/day. In conclusion, there was a J-shaped association between dietary zinc intake and new-onset hypertension in general Chinese adults, with an inflection point at about 10.9 mg/day.

关键词： dietary zinc intake     new-onset hypertension     general population     CHNS    

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of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective cohort

《医学前沿（英文）》   页码 867-877 doi: 10.1007/s11684-023-0995-9

摘要： Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of inactivated vaccines is not well characterized in people with comorbidities, who are at high risk of severe infection. We compared the risk of SARS-CoV-2 infection after complete vaccination with Sinopharm/BBIBP in people with comorbidities (e.g., autoimmune diseases, cardiovascular disease, chronic lung disease, and diabetes) with healthy individuals using a Cox-proportional hazard model. In July–September 2021, a total of 10 548 people (comorbidities, 2143; healthy, 8405) receiving the complete primary series of vaccination with Sinopharm/BBIBP in Bangkok, Thailand were prospectively followed for SARS-CoV-2 infection through text messaging and telephone interviewing for 6 months. A total of 295 infections from 284 participants were found. HRs (95% CI) of individuals with any comorbidities did not increase (unadjusted, 1.02 (0.77–1.36), P = 0.89; adjusted, 1.04 (0.78–1.38), P = 0.81). HRs significantly increased in the subgroup of autoimmune diseases (unadjusted, 2.64 (1.09–6.38), P = 0.032; adjusted, 4.45 (1.83–10.83), P = 0.001) but not in cardiovascular disease, chronic lung disease, or diabetes. The protection against SARS-CoV-2 infection of the Sinopharm vaccine was similar in participants with any comorbidities vs. healthy individuals. However, the protection appeared lower in the subgroup of autoimmune diseases, which may reflect suboptimal immune responses among these people.

关键词： COVID-19     Sinopharm/BBIBP vaccine     immunocompromised patients     real-world    

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fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohort

《医学前沿（英文）》 2022年 第16卷 第5期   页码 714-722 doi: 10.1007/s11684-021-0888-8

摘要： A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been proposed. We aim to examine the associations of MAFLD, particularly its discordance from non-alcoholic fatty liver disease (NAFLD), with the progression of elevated brachial-ankle pulse wave velocity (baPWV) and albuminuria in a community-based study sample in Shanghai, China. After 4.3 years of follow-up, 778 participants developed elevated baPWV and 499 developed albuminuria. In comparison with the non-MAFLD group, the multivariable adjusted odds ratio (OR) of MAFLD group for new-onset elevated baPWV was 1.25 (95% confidence interval (CI) 1.01–1.55) and 1.35 (95% CI 1.07–1.70) for albuminuria. Participants without NAFLD but diagnosed according to MAFLD definition were associated with higher risk of incident albuminuria (OR 1.77; 95% CI 1.07–2.94). Patients with MAFLD with high value of hepamet fibrosis score or poor-controlled diabetes had higher risk of elevated baPWV or albuminuria. In conclusion, MAFLD was associated with new-onset elevated baPWV and albuminuria independently of body mass index, waist circumference, and hip circumference. Individuals without NAFLD but diagnosed as MAFLD had high risk of albuminuria, supporting that MAFLD criteria would be practical for the evaluation of long-term risk of subclinical atherosclerosis among fatty liver patients.

关键词： metabolic dysfunction-associated fatty liver disease     non-alcoholic fatty liver disease     fibrosis score     brachial-ankle pulse wave velocity     albuminuria    

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Association of maternal depression with dietary intake, growth, and development of preterm infants: a cohort

Han Wang, Hong Zhou, Yan Zhang, Yan Wang, Jing Sun

《医学前沿（英文）》 2018年 第12卷 第5期   页码 533-541 doi: 10.1007/s11684-017-0591-y

摘要：

This study aimed to explore the association of maternal depression with nutrient intake, growth, and development of preterm infants. A cohort study of 201 infants was conducted in Beijing. Based on the gestational age of an infant and status of the mother, the infants were divided into four groups: non-depression-fullterm (64), non-depression-preterm (70), depression-fullterm (36), and depression-preterm (31). Data on sociodemographic characteristics, nutritional intake, growth, and developmental status of children at 8 months (corrected ages) were collected using a quantitative questionnaire, a 24-Hour Dietary Recall, anthropometric measurements, and the Bayley-III scale. A multivariate analysis was used to evaluate the effects of maternal depression and preterm birth on infant growth and development. The energy, protein, and carbohydrate intake in the depression group was lower than the recommended amounts. The depression preterm groups indicated the lowest Z-scores for length and weight and the lowest Bayley-III scores. Preterm infants of depressed mothers are at high risks of poor growth and development delay.

关键词： maternal depression     preterm     infant     nutrition     growth     development    

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characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort

《医学前沿（英文）》 2022年 第16卷 第1期   页码 111-125 doi: 10.1007/s11684-021-0854-5

摘要： The coronavirus disease 2019 (COVID-19) has spread globally. Although mixed liver impairment has been reported in COVID-19 patients, the association of liver injury caused by specific subtype especially chronic hepatitis B (CHB) with COVID-19 has not been elucidated. In this multi-center, retrospective, and observational cohort study, 109 CHB and 327 non-CHB patients with COVID-19 were propensity score matched at an approximate ratio of 3:1 on the basis of age, sex, and comorbidities. Demographic characteristics, laboratory examinations, disease severity, and clinical outcomes were compared. Furthermore, univariable and multivariable logistic and Cox regression models were used to explore the risk factors for disease severity and mortality, respectively. A higher proportion of CHB patients (30 of 109 (27.52%)) developed into severe status than non-CHB patients (17 of 327 (5.20%)). In addition to previously reported liver impairment markers, such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total bilirubin, we identified several novel risk factors including elevated lactate dehydrogenase (≥245 U/L, hazard ratio (HR) = 8.639, 95% confidence interval (CI) = 2.528–29.523; P <0.001) and coagulation-related biomarker D-dimer (≥0.5 μg/mL, HR= 4.321, 95% CI= 1.443–12.939; P = 0.009) and decreased albumin (<35 g/L, HR= 0.131, 95% CI= 0.048–0.361; P <0.001) and albumin/globulin ratio (<1.5, HR= 0.123, 95% CI= 0.017–0.918; P = 0.041). In conclusion, COVID-19 patients with CHB were more likely to develop into severe illness and die. The risk factors that we identified may be helpful for early clinical surveillance of critical progression.

关键词： COVID-19     chronic hepatitis B     liver injury     coagulation dysfunction    

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Long-term exposure to air pollution and cerebrovascular disease: findings from Beijing Health Management Cohort

《环境科学与工程前沿（英文）》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1684-2

摘要：

● This study explored the long-term association by double robust additive models.

关键词： Air pollution     Cerebrovascular disease     Incidence     Long-term exposure     Doubly robust additive model    

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基于就医人群的中国多囊卵巢综合征女性的临床表型和治疗结局—— 身体质量指数与地理分布的影响 Article

高敬书, 马红丽, 王宇, 杨新鸣, 曹义娟, 张蓓, 韩丛辉, 吴效科

《工程（英文）》 2021年 第7卷 第2期   页码 170-177 doi: 10.1016/j.eng.2020.12.006

摘要：

遗传因素、生活方式和环境因素与多囊卵巢综合征（PCOS）的发生相关。身体质量指数（BMI）的增加会加剧生殖及代谢障碍，降低PCOS女性的生育能力。本文对在中国大陆21个研究中心开展的一项大样本、多中心、随机对照试验进行二次分析。共有1000名PCOS女性参加本试验。其中，998名PCOS女性被纳入分析。BMI增加与月经失调加剧、高睾酮水平、高代谢综合征患病率以及生活质量降低相关。BMI正常组、超重组和肥胖组的女性人均排卵率分别为83.0%、78.2%和63.6%（P < 0.001），活产率分别为23.6%、18.1%和15.3%（P = 0.030）。与中国南方的PCOS患者相比，北方的PCOS患者生殖结局较差，血糖和血脂代谢不良，运动量少，以及总排卵率更低（81.2% vs 74.8%，绝对差：6.4%，95%置信区间：1.2%~11.5%）。结果显示，中国南北方的汉族PCOS女性具有典型的表型特征。与生活在中国南方的女性相比，在同样的干预措施下，中国北方的女性BMI更高，糖脂代谢障碍更严重，临床结局更差。表型特征及排卵的差异可以通过BMI差异加以解释。

关键词： 多囊卵巢综合征     体重指数     表型     中国队列     地理分布    

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mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort

《医学前沿（英文）》 doi: 10.1007/s11684-023-1014-x

摘要： This cohort study was performed to explore the influence of intensive care unit (ICU) quality on in-hospital mortality of veno-venous (V-V) extracorporeal membrane oxygenation (ECMO)-supported patients in China. The study involved all V-V ECMO-supported patients in 318 of 1700 tertiary hospitals from 2017 to 2019, using data from the National Clinical Improvement System and China National Critical Care Quality Control Center. ICU quality was assessed by quality control indicators and capacity parameters. Among the 2563 V-V ECMO-supported patients in 318 hospitals, a significant correlation was found between ECMO-related complications and prognosis. The reintubation rate within 48 hours after extubation and the total ICU mortality rate were independent risk factors for higher in-hospital mortality of V-V ECMO-supported patients (cutoff: 1.5% and 7.0%; 95% confidence interval: 1.05–1.48 and 1.04–1.45; odds ratios: 1.25 and 1.23; P = 0.012 and P = 0.015, respectively). Meanwhile, the V-V ECMO center volume was a protective factor (cutoff of ≥ 50 cases within the 3-year study period; 95% confidence interval: 0.57–0.83, odds ratio: 0.69, P = 0.0001). The subgroup analysis of 864 patients in 11 high-volume centers further strengthened these findings. Thus, ICU quality may play an important role in improving the prognosis of V-V ECMO-supported patients.

关键词： veno-venous extracorporeal membrane oxygenation     in-hospital mortality     high-volume centers     quality control     intensive care unit capacity parameters    

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基于同类用户的个性化查询词自动推荐方法 Regular Papers-Research Articles

Dan-yang JIANG, Hong-hui CHEN

《信息与电子工程前沿（英文）》 2019年 第20卷 第9期   页码 1246-1258 doi: 10.1631/FITEE.1800010

摘要： 查询词自动推荐（query auto-completion，QAC）通过预测查询词前缀对应的完整补全查询词帮助用户构造查询词。大多互联网搜索引擎利用用户的行为信息为用户提供个性化的查询词自动推荐列表。为提高推荐成功率，个性化的QAC方法需获取大量关于用户搜索兴趣和搜索意图的上下文信息。因此，这些方法通常受制于用户数据的稀疏性问题。本文提出利用同类用户的搜索记录解决用户数据的稀疏性问题，并提升个性化QAC方法的推荐性能。首先，通过主题模型得到用户的主题兴趣，建立每个用户的兴趣肖像，然后将兴趣肖像相似的用户聚集起来建立同类用户群。由于传统主题模型不能自动识别同类用户，提出两个同类用户主题模型，将主题建模与同类用户识别包含在同一个模型框架内。根据不同的同类用户识别方法，提供4个不同的基于同类用户的个性化QAC方法。所提个性化QAC方法通过同类用户的上下文信息和查询词的频率对补全的查询词排序。在公开的AOL查询词数据集上进行大量实验，并与不采用同类用户上下文信息的方法进行排序性能对比。实验结果显示，本文提出的基于同类用户的个性化QAC方法能有效解决用户数据稀疏性问题，并且相对于基准方法能大幅提升排序结果准确性。

关键词： 查询词自动推荐；基于同类用户的信息检索；主题模型    

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一种通过检测特定粪便微生物群来评估人体肠道微生物稳态的方法 Article

Zhongwen Wu, Xiaxia Pan, Yin Yuan, Pengcheng Lou, Lorina Gordejeva, Shuo Ni, Xiaofei Zhu, Bowen Liu, Lingyun Wu, Lanjuan Li, Bo Li

《工程（英文）》 2023年 第29卷 第10期   页码 110-119 doi: 10.1016/j.eng.2023.03.007

摘要：

Research on microecology has been carried out with broad perspectives in recent decades, which has enabled a better understanding of the gut microbiota and its roles in human health and disease. It is of great significance to routinely acquire the status of the human gut microbiota; however, there is no method to evaluate the gut microbiome through small amounts of fecal microbes. In this study, we found ten predominant groups of gut bacteria that characterized the whole microbiome in the human gut from a largesample Chinese cohort, constructed a real-time quantitative polymerase chain reaction (qPCR) method and developed a set of analytical approaches to detect these ten groups of predominant gut bacterial species with great maneuverability, efficiency, and quantitative features. Reference ranges for the ten predominant gut bacterial groups were established, and we found that the concentration and pairwise ratios of the ten predominant gut bacterial groups varied with age, indicating gut microbial dysbiosis. By comparing the detection results of liver cirrhosis (LC) patients with those of healthy control subjects, differences were then analyzed, and a classification model for the two groups was built by machine learning. Among the six established classification models, the model established by using the random forest algorithm achieved the highest area under the curve (AUC) value and sensitivity for predicting LC. This research enables easy, rapid, stable, and reliable testing and evaluation of the balance of the gut microbiota in the human body, which may contribute to clinical work.

关键词： Gut microbiota     Machine learning     Microbial dysbiosis     Quantitative polymerase chain reaction     Chinese cohort    

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5p and urinary albumin excretion rates in patients with type 2 diabetes mellitus: a cross-sectional cohort

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

《医学前沿（英文）》 2020年 第14卷 第5期   页码 642-650 doi: 10.1007/s11684-019-0719-3

摘要： This study aimed to investigate the correlation between serum miR-154-5p and urinary albumin to creatinine ratio (UACR) in patients with type 2 diabetes mellitus (T2DM) and the association with biomarkers of inflammation and fibrosis in diabetic kidney disease (DKD). A total of 390 patients with T2DM were divided into three groups: normal albuminuria (UACR<30 mg/g, =136, NA), microalbuminuria (UACR at 30–300 mg/g, =132, MA), and clinical albuminuria (UACR>300 mg/g, =122, CA). Circulating miR-154-5p, inflammatory (C-reactive protein (CRP); erythrocyte sedimentation rate (ESR); and tumor necrosis factor-α (TNF-α) and fibrotic markers (vascular endothelial growth factor (VEGF); transforming growth factor-β1 (TGF-β1); and fibronectin (FN)), and other biochemical indicators were assessed via real-time PCR, enzyme-linked immunosorbent assay, and chemiluminescence assay in patients with T2DM and 138 control subjects (NC). UACR, miR-154-5p, glycated hemoglobin (HbA1c), serum creatinine (sCr), blood urea nitrogen (BUN), ESR, CRP, VEGF, TNF-α, TGF-β1, and FN were significantly higher and the estimated glomerular filtration rate (eGFR) was significantly lower in NA, MA, and CA groups than in NC subjects ( <0.05). Elevated levels of UACR and miR-154-5p were directly correlated with HbA1c, sCr, BUN, ESR, CRP, VEGF, TNF-α, TGF-β1, and FN and negatively correlated with eGFR ( <0.05). miR-154-5p, HbA1c, sCr, BUN, eGFR, ESR, CRP, VEGF, TNF-α, TGF-β1, and FN were important factors affecting UACR. These findings indicated that elevated serum miR-154-5p is significantly correlated with high UACR in patients with T2DM and may offer a novel reference for the early diagnosis of DKD.

关键词： type 2 diabetes mellitus     diabetic kidney disease     miR-154-5p     urinary albumin to creatinine ratio    

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Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19

《医学前沿（英文）》 doi: 10.1007/s11684-023-1040-8

摘要： Traditional Chinese medicine (TCM) has played an important role in the prevention and treatment of coronavirus disease 2019 (COVID-19) epidemic in China. The integration of Chinese and Western medicine is an important feature of Chinese COVID-19 prevention and treatment. According to a series of evidence-based studies, TCM can reduce the infection rate of severe acute respiratory syndrome coronavirus 2 in high-risk groups. For patients with mild and moderate forms of COVID-19, TCM can relieve the related signs and symptoms, shorten the period of nucleic-acid negative conversion, and reduce conversion rate to the severe form of the disease. For COVID-19 patients with severe and critical illnesses, TCM can improve inflammatory indicators and blood oxygen saturation, shorten the hospital stay, and reduce the mortality rate. During recovery, TCM can improve patients’ symptoms, promote organ function recovery, boost the quality of patients’ life, and reduce the nucleic-acid repositive conversion rate. A series of mechanism research studies revealed that capability of TCM to treat COVID-19 through antiviral and anti-inflammatory effects, immune regulation, and protection of organ function via a multicomponent, multitarget, and multipathway approach.

关键词： traditional Chinese medicine     COVID-19     SARS-CoV-2     clinical evidence-based study     mechanism     integrated traditional Chinese and Western medicine    

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标题 作者 时间 类型 操作

Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospectivecohort study

Di Cheng, Chunyan Hu, Rui Du, Hongyan Qi, Lin Lin, Xueyan Wu, Lina Ma, Kui Peng, Mian Li, Min Xu, Yu Xu, Yufang Bi, Weiqing Wang, Yuhong Chen, Jieli Lu

期刊论文

Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

期刊论文

fertility-sparing surgery for non-epithelial ovarian tumors to safely and successfully become pregnant---a Chineseretrospective cohort study among 148 cases

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

期刊论文

J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study

期刊论文

of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective cohort

期刊论文

fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohort

期刊论文

Association of maternal depression with dietary intake, growth, and development of preterm infants: a cohort

Han Wang, Hong Zhou, Yan Zhang, Yan Wang, Jing Sun

期刊论文

characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort

期刊论文

Long-term exposure to air pollution and cerebrovascular disease: findings from Beijing Health Management Cohort

期刊论文

基于就医人群的中国多囊卵巢综合征女性的临床表型和治疗结局—— 身体质量指数与地理分布的影响

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